Monday, June 18, 2012

Pseudo-Wellens' Syndrome due to Left Ventricular Hypertrophy (LVH)

A 52 year old male presented with epigastric pain, continuing in the emergency department.  He has a history of hypertension, and is on amlodipine.  Thinking that epigastric pain might be an anginal equivalent, this ECG was recorded:

There is LVH.  There are T-wave inversions in aVL and V3-V6. 

The physicians were worried about Wellens' syndrome and treated for ACS.  He was placed on a nitroglycerine drip.  Initial troponin was negative.  A followup ECG was done 3 hours later.

Perhaps slightly less T-wave inversion.  Nonspecific.

He was admitted.  All troponins were normal.  A formal echo showed concentric LVH and there was also a subtle abnormality which the echocardiographer thought suspicious for LAD distribution ischemia.  So he underwent a coronary angiogram which was completely normal.

This is not Wellens'.  Why?

1.  LVH frequently causes T-wave inversion which mimics Wellens'
2.  In Wellens', the chest pain is nearly always resolved by the time of the ECG.  It is reperfusion that results in the T-wave inversion and the pain is thus resolved by this time.
3.  Wellens' is defined by chest pain and ECG abnormalities.  Though Acute MI can present as epigastric pain, it is not at all common and T-wave inversion in the setting of epigastric pain is not high risk for ACS.
4.  T-wave inversion in Wellens' is primarily V2-V4.  When T-wave inversion is V3-V6, one should think more about LVH or Benign T-wave Inversion (this post on Benign T-wave Inversion is worth reading)


  1. Very interesting, thank you so much.

  2. Excuse me please how could you know that the t wave inversions are not due to NSTEMI ?

    1. For me, I simply recognize the pattern. I have seen so many.

      For others, I just recommend that you think about LVH and, if there is LVH, you must suspect a false positive, as in this case.

  3. Hello.. If LVH is diagnosed by lead aVL>11mm criteria n chest leads amplitude being normal, would those wellens waves still be called wallens or pseudo wellens? Thx

    1. No simple answer. Criteria are not very good for LVH. And much LVH does not have repolarization abnormalities, so this does not apply to all LVH. To know this is not Wellens', you need the totality of the presentation: Not chest pain (epigastric), still ongoing, T-wave inversion V3-V6, AND LVH. No one thing will give you the answer.

  4. What criteria did you use for LVH in this patient

    1. I didn't use criteria. Just looked at it and knew. But if you do apply the best criteria (recently published), it is LVH.

      New LVH criteria: sum of the amplitude of the deepest S wave in any lead plus the S wave in lead V4. If the deepest S wave is in V4, then double that value. If the total is greater than 2.3 in women and
      greater than 2.8 in men then left ventricular hypertrophy is diagnosed.

      Peguero JG et al. Electrocardiographic criteria for the diagnosis of left ventricular Hypertrophy. JACC 69(23):1694-1703; April 4, 2017


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